DNL343 is an investigational CNS penetrant eIF2B activator that prevents and reverses the effects of neurodegeneration ...
Eukaryotic initiation factor 2B (eIF2B) is a heterodecameric protein that plays an indispensable role in regulating translation of mRNA into protein. This process is initiated by the assembly of GTP-bound eIF2 and methionine-carrying initiator tRNA (Met- …