The Study of PIK3CA Hotspot Mutations and Co-Occurring with EGFR, KRAS, and TP53 Mutations in Non-Small Cell Lung Cancer
Introduction Phosphoinositide-3-kinase (PI3Kα), which is composed of a catalytic subunit p110α and a regulatory subunit p85α, catalyzes the phosphorylation of phosphatidylinositol 4.5-bisphosphate (PIP2) to phosphatidylinositol 3,4,5-trisphosphate (PIP3), …