
Significantly Increased Aqueous Solubility of Piperine via Nanoparticle Formulation Serves as the Most Critical Factor ...
Introduction Piperine, 1-(5-(1,3-benzodioxol-5-yl)-1-oxo-2,4-pentadienyl), is a natural compound found in Piper retrofractum and Piper nigrum. It had a molecular weight of 285.34 and a water solubility of 0.04 mg/mL.1 Research demonstrated that …